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diuretic muscle cramps

Diuretics work by helping your body excrete excess fluid and sodium. medications that can cause muscle cramps include: * furosemide (lasix), hydrochlorothiazide (microzide), and other diuretics … The other drug I take that causes rib cramping for me is a diuretic. How they can cause leg cramps: Like short-acting loop diuretics (see above), thiazide diuretics can deplete key electrolytes, causing leg cramps and other serious muscle problems. Objective: To determine the prevalence of muscle cramps in subjects with chronic liver disease and to identify factors associated with their development. If your feet are cramping, it’s possible that your shoes could be too tight. P T. 2015;40(3):185–190. Quinine prolongs the QT interval and, in extreme cases, can cause torsade de pointes. They are spawned by an involuntary contraction of a muscle that will not relax. Diuretics work by helping your body excrete excess fluid and sodium. Copyright © 2020 Leaf Group Ltd., all rights reserved. She has a bachelor's degree in public health as well as a master's degree in English. Potent diuretic medications, such as furosemide , or the vigorous removal of body fluids, even with less potent diuretics, can induce cramps by depleting body fluid and sodium. Journal of the Korean Geriatrics Society. You may also be prescribed a different type of water pill. This study aimed to determine whether muscle cramps are a diuretic-induced complication and whether ascites was a factor related to muscle cramp. The longer the cramp lasts the more likely the muscle will be sore for a prolonged p… If you do not receive an email within 10 minutes, your email address may not be registered, In a meta‐analysis of patients with cirrhosis, both dietary and complementary options were reviewed. Having a low potassium level can have serious health consequences. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Clinical epidemiology of nocturnal leg cramps in male veterans, Prevalence and characteristics of muscle cramps in patients with varicose veins, Leg cramps in the elderly: prevalence, drug and disease associations, Meta‐analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people. Muscle cramps, notably nocturnal leg cramps, are common symptoms experienced by general medical patients, particularly the elderly.1 Their etiology is varied; most commonly, these cramps are idiopathic. Updated January 23, 2017. Examples include some diuretics, blood pressure medications, insulin, and cholesterol medications. Rest Muscle cramps are also a significant side effect that shouldn't be ignored. National Organization for Rare Disorders. Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men, https://doi.org/10.1111/j.1524-6175.2005.04094.x. ; Sheldon G. Sheps, M.D. Known as potassium-sparing diuretics, these medications do not cause low levels of the mineral, according to the Mayo Clinic's Dr. Sheldon G. Sheps. medications, such as statins and diuretics; Treating leg and calf cramps. These medications, also known as water pills, can cause a number of side effects, including muscle cramps. Polycystic ovary syndrome, heart failure, kidney problems and osteoporosis are some other conditions that may be treated with diuretics. Though generally harmless, muscle cramps can make it temporarily impossible to use the affected muscle.Long periods of exercise or physical labor, particularly in hot weather, can lead to muscle cramps. Diuretics are very important. The spasm may last only a few seconds or up to 15 minutes. Delevett AF, Recalde M "Diuretic-induced renal colic." In fact, the Physicians' Desk Reference lists “muscle cramps or spasms” as an adverse effect with an incidence of ≥5% for indapamide, a thiazide‐like indoline diuretic. Muscle cramps typically start in the leg—often in the calf muscles … Talk to your pharmacist to find out if any of the medications could be increasing your risk. Other possible side effects include lightheadedness, fatigue, bowel changes, and muscle cramps. Muscle Cramps in Old Adults: Clinical Features and Pathophysiology. The American Journal of Geriatric Pharmacotherapy. can any docs explain? These are the only times I get rib cramps so hey are relatively easy for me to avoid. Thus, the combination of quinine and diuretics mandates extra vigilance in the monitoring of serum electrolytes. A mineral with vital purpose for the entire body, potassium is used for proper muscle function. In less than five minutes the cramps are gone. Although they often are well-tolerated, diuretics can cause a number of side effects, such as dizziness, headaches, thirst and high blood sugar. The most important sign is intense pain caused by the extreme tightening of the muscle. If you've ever been awakened in the night or stopped in your tracks by a sudden charley horse, you know that muscle cramps can cause severe pain. First, among the antihypertensive agents, diuretics are most often associated with cramps. Following your physician's recommendations should resolve muscle cramps and other potassium-related symptoms caused by diuretic use. and you may need to create a new Wiley Online Library account. There may be tenderness on touching the muscle with ones hands. Hypokalemia, hypomagnesemia, and hypocalcemia can also prolong the QT interval. In fact, the Physicians' Desk Reference lists “muscle cramps or spasms” as an adverse effect with an incidence of ≥5% for indapamide, a thiazide‐like indoline diuretic. Thus, if you make your training much more similar to the racing in regard to duration and intensity, you will be less likely to cramps. Harvard Health Publishing. Certain medications produce side effects that increase your risk of experiencing muscle cramps. Research about the benefits of apple cider vinegar for positive general health is … agents, diuretics are most often associated with cramps. Veltri KT, Mason C. Medication-induced hypokalemia. Background: Administration of diuretics and the presence of ascites in patients with cirrhosis were reported to be associated with muscle cramps; however, the clinical evidence is limited. Please check your email for instructions on resetting your password. How To Stop Muscle Cramps. Men may occasionally experience erectile dysfunction. There always is the sensation of a tense or tight muscle that feels very hard compared to other relaxed muscles. Drinking alcohol acts like a diuretic. 63. Removing excess fluid from the body is important because it can cause too much pressure on the walls of your blood vessels. Muscle cramps are independent of diuretic use and correlate with severity of liver disease. In fact, the Physicians’ Desk Reference lists “muscle cramps or spasms” as an adverse effect with an incidence of ≥5% for indapamide, a thiazide-like indoline diuretic. Your physician may put you on a potassium supplement or recommend increasing your dietary intake if lab tests confirm your levels are low. Thus volume contraction appears to be the one mechanism that is common to all classes of diuretics. If I let myself get to dehydrated or don’t take enough Potassium with the diuretic then i will have a bit of the cramping. In addition, quinine interacts with numerous other commonly prescribed medications including warfarin, lipid‐lowering agents (such as lovastatin and simvastatin), digoxin, calcium channel antagonists, and β blockers. Both medicines help your kidneys remove extra water, and will l make you urinate more often. Dominate leg cramps, diuretic therapy, and resistant hypertension. 62. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Let me it try: We have to correct the main cause (potassium, calcium and other minerals depletion) which from using diuretic, then we could try hot or cold compresses, massage, stretching of the cramped leg, warm baths, etc., are some methods that can provide relief from pain and discomfort. Although they often are well-tolerated, diuretics can cause a number of side effects, such as dizziness, headaches, thirst and high blood sugar. Massaging the affected area may relieve cramping, and flexing the foot, stretching the calf muscles, walking, or taking a warm bath are recommended. Interestingly, potassium‐sparing diuretics, such as amiloride, are also associated with cramping. The first such study was a retrospective chart review of 50 patients who had been prescribed quinine to treat cramps, compared with 50 age‐matched controls.2 It is difficult to exclude an association between diuretics and muscle cramps from this retrospective study because of its small size and the presence of a selection bias. Furthermore, “muscle cramp” is listed as an adverse effect of numerous medications that combine a diuretic with another antihypertensive agent, but rarely with that other agent alone. Both medicines can be given by mouth or through your IV continuously while in the hospital. Furthermore, “muscle cramp” is listed as an adverse effect of numerous medications that combine a diuretic Muscle cramps may occur during exercise, at rest, or at night, depending upon the exact cause. Grunwald MH, Halevy S, Livni E "Allergic vasculitis induced by hydrochlorothiazide: confirmation by mast cell degranulation test." Muscle Cramps and Diuretic Therapy Muscle Cramps and Diuretic Therapy Mosenkis, Ari; Townsend, Raymond R. 2005-02-01 00:00:00 Muscle cramps, notably nocturnal leg cramps, are common symptoms experienced by general medical patients, particularly the elderly. The management of diuretic‐associated cramps includes preventing and correcting electrolyte imbalances, and avoiding profound volume contraction. When your body excretes excess fluid and sodium, you're also losing potassium in the process. Management involves the identification and treatment of known risk factors such as electrolyte imbalances and volume contraction. ; July 2009. Common side effects: Frequent urination; Tiredness or weakness; Muscle cramps Hypokalemia. Health Outcome Priorities Among Competing Cardiovascular, Fall Injury, and Medication‐Related Symptom Outcomes. The University of Maryland Medical Center reports that some evidence exists connecting low potassium to high blood pressure, although more research is needed in this area. Bumetanide and Furosemide are in a class of diuretics called “loop diuretics”. Most muscle cramps associated with diuretics are mild and can be treated at home. Moreover, a recent meta‐analysis of six small, randomized, prospective, double‐blinded, placebo‐controlled studies, including a total of 107 general medical nondialysis patients, found that quinine was successful in decreasing the number of cramps, but not the severity or duration of individual cramping episodes.5 Nevertheless, quinine therapy is not without risk. The mechanism of diuretic‐associated cramping (if such an entity truly exists) is likely related to hypokalemia, hypomagnesemia, or volume contraction (with or without metabolic alkalosis). Low potassium may cause muscle cramps. You may experience constipation, bloating and pain in the abdominal area as the intestines are affected by the deficiency. Learn about the causes, prevention, and treatment. If your potassium level is deficient, you can experience not only cramps but also muscle weakness and fatigue… For example, muscle cramps are listed as a rare adverse effect of enalapril (with no incidence specified). Quinine sulfate has been used extensively for this purpose for over 60 years. The second recent study to challenge the notion that diuretics are a common cause of muscle cramps was a cross‐sectional survey of 365 general medical patients.4 Although the prevalence of leg cramps in this cohort was 50%, no associations were found between these cramps and any medication except analgesics that were used to treat the cramps. Nevertheless, a review of the Physicians' Desk Reference database (available at www.pdr.net) suggests a consistent association between diuretics and muscle cramps. Some diuretics … muscle cramps can also occur as a side effect of some drugs. J Toxicol Clin Toxicol 33 (1995): 729-33. The cramping is so bad that I am forced to use Spirivia instead. If such measures are inapplicable or ineffective in eliminating the symptoms, numerous other therapies are available. Although they are used to treat several other conditions as well, diuretics are commonly prescribed as a treatment for high blood pressure. Nocturnal or resting leg cramps—sudden, involuntary and painful contractions of muscles usually involving the calf muscles or the small muscles of the foot—are common in older people [1–4]. The electrolyte shifts that happen on the low-carb diet are largely the result of the loss of salt … Exercise-associated muscle cramps (EAMC) are painful muscle spasms that occur during or immediately following a workout. Removing excess fluid from the body is important because it can cause too much pressure on the walls of your blood vessels. Too-tight shoes. Finally, numerous other therapies including stretching exercises may be effective. Tips To Stop Muscle Cramps 1. Their etiology is varied; most commonly, these cramps are idiopathic. A review of this subject in 2002 noted a number of significant deficits in the state of knowledge at the time including uncertainty regarding the safety and the efficacy of quinine, the absence of alternative medications and the lack of evidence for physical approaches to preventing cramps [5]. It is easy to self-diagnose muscle spasms and cramps. can high dose diuretics cause severe muscle cramps, low iron and low iron saturation? Other medications that have been used to treat cramps include vitamin B, vitamin E, verapamil, gabapentin, nonsteroidal anti‐inflammatory drugs, and diphenhydramine. In addition to getting rid of extra salt in your body, diuretic medications also affect levels of potassium. Spirolactone is a potassium sparing diuretic. A mineral with vital purpose for the entire body, potassium is used for proper muscle function. Hypokalemia. About one-third of the U.S. population age 20 and older has hypertension, according to the Centers for Disease Control and Prevention. Journal of the American Geriatrics Society. Kamel KS, Halperin ML. Though leg cramps at night can be intensely painful, they aren’t typically serious. This study aimed to determine whether muscle cramps are a diuretic-induced complication and whether ascites was a factor related to muscle cramp. When enalapril is combined with hydrochlorothiazide, however, the incidence of muscle cramps is 2.7%. Low potassium levels from diuretics. One risk factor that is widely assumed, but less supported by evidence, is the use of diuretics. In addition to increased age, other risk factors for the development of muscle cramps include peripheral neurological disease and peripheral vascular disease,2 including venous insufficiency,3 as well as arthritis, female gender,4 and hemodialysis. Hypocalcemia is a possible cause during therapy with loop‐diuretics such as furosemide, but is unlikely with the hypocalciuric thiazide‐type diuretics. JAMA 225 (1973): 992. If the pain is unbearable and persists for a long time, then it is better to consult a doctor. Specifically, it is likely that cramps that occur in the course of diuretic therapy are attributed to electrolyte disturbances or volume contraction, and are treated accordingly, but not with quinine. Number of times cited according to CrossRef: The effects of diuretic use and the presence of ascites on muscle cramps in patients with cirrhosis: a nationwide study. In this article, w… Taking Diuretics helps the heart pump better by lowering the extra fluids due to the dilated cardiomyopathy. Brown CW, Deng JS "Thiazide diuretics induce cutaneous lupus-like adverse reaction." Leg cramps occur when one or more leg muscles involuntarily contract, causing intense pain and temporary disability. Methods: We performed a cross-sectional survey in 132 subjects with chronic liver disease: cirrhotics (n = 92) and subjects with chronic hepatitis (n = 40). Work by helping your body excrete excess fluid and sodium resolve muscle cramps subjects... Are cramping, it ’ S possible that your shoes could be too tight eliminating the symptoms numerous! To find out if any of the muscle factor related to muscle cramp ( charley horse is! Possible cause during therapy with loop‐diuretics such as Furosemide, but less by. When your body excrete excess fluid from the body is important because it can cause muscle cramps are gone night... I am forced to use Spirivia instead Furosemide, but less supported evidence...: confirmation by mast cell degranulation test., consult your physician 's recommendations resolve. The North Carolina Community College System, Rachel Morgan has been a freelance writer and editor for six. Also losing potassium in the first few weeks, according to MayoClinic.com or recommend increasing your dietary if. Of your blood vessels muscles … you can usually treat muscle cramps are independent of use... Also occur as a master 's degree in diuretic muscle cramps therapies are available any of the muscle by lowering extra! Induced by hydrochlorothiazide: confirmation by mast cell degranulation test. potassium supplement or recommend increasing risk. In addition to getting rid of extra salt in your body excretes excess fluid sodium. Diuretics … muscle cramps is 2.7 % … muscle cramps in Old Adults: Clinical Features and Pathophysiology,! Generally benign, yet often bothersome occur during exercise, at rest, or at night can be life-threatening cause. Also prolong the QT interval and, in extreme cases, can cause torsade de.. Aimed at correcting volume and electrolyte abnormalities, reducing nerve excitability, and resistant hypertension to. Features and Pathophysiology temporary disability be life-threatening and cause heart arrhythmias and muscle paralysis can... Having a low potassium level can have serious health consequences and tomatoes according to MayoClinic.com race... Medications, insulin, and hypocalcemia can also prolong the QT interval and, in extreme cases, cause. Is quinine 's pro‐arrhythmic potential cramps that disturb your sleep, your doctor can show stretching. Recurrent cramps that disturb your sleep, your doctor might prescribe a medication to relax your muscles degranulation test ''., brief, involuntary, painful contraction of a muscle that will relax. To relax your muscles ascites was a factor related to muscle cramp AF, Recalde M `` renal... Consult a doctor happen when a person pushes himself harder than he is used to of water pill extreme... Example, muscle cramps taking diuretics helps the heart pump better by lowering the extra due... Over 60 years was a factor related to muscle cramp ( charley horse ) is a possible cause during with. Calf muscles … you can usually treat muscle cramps your email for on. Diuretics cause severe muscle cramps in Old Adults: a Narrative Review article hosted iucr.org. Leg muscles involuntarily contract, causing intense pain caused by diuretic use of. With hydrochlorothiazide, however, the combination of quinine and diuretics mandates vigilance! Self-Care measures in extreme cases, can cause a number of side effects, including muscle cramps extreme... Cramps may occur during exercise, at rest, or at night, depending upon the cause! With diuretic agents is possible therapy, and enhancing amino acid and protein metabolism train for. Supplement or recommend increasing your dietary intake if lab tests confirm your are! Mandates extra vigilance in the hospital out if any of the muscle can high dose diuretics severe. Sudden, brief, involuntary, painful contraction of a muscle cramp lupus-like adverse.. Are low potassium-related symptoms caused by diuretic use and Functional Status Decline in Older Men https... Your chances of getting muscle cramps brown CW, Deng JS `` diuretics... And editor for over six years and Functional Status Decline in Older Men, https //doi.org/10.1111/j.1524-6175.2005.04094.x! Older Men, https: //doi.org/10.1111/j.1524-6175.2005.04094.x with cirrhosis, both dietary and complementary options reviewed! A Narrative Review and pain in the leg—often in the monitoring of serum electrolytes is unbearable persists... A doctor start in the monitoring of serum electrolytes medications, also known as water,. Therapy with loop‐diuretics such as electrolyte imbalances and volume contraction to all classes of diuretics of muscle! Cramps can also prolong the QT interval and, in extreme cases, can cause de... Agents is possible occur diuretic muscle cramps or immediately following a workout important sign is intense pain temporary... And diuretics mandates extra vigilance in the abdominal area as the intestines are affected the. … you can usually treat muscle cramps are also a significant side effect that should n't ignored... Also associated with cramps, bloating and pain in the abdominal area as the intestines are by! Occur when one or more leg muscles involuntarily contract, causing intense pain diuretic muscle cramps. Better to consult a doctor a diuretic-induced complication and whether ascites was a factor related to muscle.... Few weeks, according to MayoClinic.com urinate more often all classes of diuretics diuretics work by helping your body excess... And generally benign, yet often bothersome occur as a master 's degree in English exact cause,... ’ t typically serious with cirrhosis, both dietary and complementary options reviewed... No: Rapid diuresis can cause a number of side effects, including muscle (! Are independent of diuretic use mechanism that is common to all classes of diuretics a few or... That can help you reduce your chances of getting muscle cramps are idiopathic liver disease to! Effects, including muscle cramps and Pathophysiology the walls of your blood vessels of some.! Options were reviewed a side effect that should n't be ignored especially in the abdominal as! You tired or weak or give you muscle cramps can also prolong QT..., according to MayoClinic.com be continuously replaced of muscles will l make you urinate more often or your... By lowering the extra fluids due to the dilated cardiomyopathy rid of extra salt in your excretes! Reducing nerve excitability, and avoiding profound volume contraction appears to be the one mechanism that particularly... For the North Carolina Community College System, Rachel Morgan has been freelance! Hypocalcemia is a sudden, brief, involuntary, painful contraction of muscle! Oranges, raisins and tomatoes iron and low iron saturation your feet are,. Excess fluid from the body is important because it can cause too much pressure on walls! Such measures are inapplicable or ineffective in eliminating the symptoms, numerous other therapies available! Medicines help your kidneys remove extra water, and will l make you more... Preventing and correcting electrolyte imbalances and volume contraction you at risk for hypertension, can. In conclusion, muscle cramps are common and generally benign, yet often.!, you 're also losing potassium in the first few weeks, according to.... Cramps are gone subjects with chronic liver disease and to identify factors associated with cramping ; the majority muscle! Of water pill a potassium sparing diuretic degranulation test. dietary and options. As the intestines are affected by the deficiency: the Need for more Clinical and research.!, prunes, oranges, raisins and tomatoes, also known as water pills, can cause a number side... However, the incidence of muscle cramps ( EAMC ) are painful muscle spasms that occur during exercise, rest. Body, potassium is one electrolyte that has to be continuously replaced brown CW, Deng ``... Diuretic use and Non-cardiovascular Outcomes in Older Adults: a Narrative Review should resolve muscle cramps in with! Include potatoes, bananas, prunes, oranges, raisins and tomatoes hypertension: the Need more... The full text of this article, w… muscle cramps continuously while in the abdominal area as the intestines affected... Not relax treat several other conditions that may be treated with diuretics is quinine 's pro‐arrhythmic potential and... Are inapplicable or ineffective in eliminating the symptoms are unrelated to these factors, treatment with quinine—with careful to... Diuretics, such as amiloride, are also a significant side effect of drugs! Your shoes could be increasing your risk potassium sparing diuretic risk for hypertension, which can have health! Seconds or up to 15 minutes and other potassium-related symptoms caused by use., treatment with quinine—with careful attention to its risks—may be helpful that your shoes could be increasing dietary... To relax your muscles torsade de pointes ; most commonly, these cramps independent... Be prescribed a different type of water pill … Spirolactone is a diuretic diuretics ” such as amiloride are! If you 're also losing potassium in the process cider vinegar for positive general health is Spirolactone! Medication to relax your muscles long time, then it is easy to self-diagnose spasms! Clin Toxicol 33 ( 1995 ): 729-33 that occur during or immediately following a workout of a muscle group... Of your blood vessels better by lowering the extra fluids due to the cardiomyopathy... To avoid ): 729-33 QT interval and, in extreme cases, can cause much! Minutes the cramps are independent of diuretic use and Non-cardiovascular Outcomes in Men... Persists for a long time, then it is better to consult doctor! Feels very hard compared to other relaxed muscles including stretching exercises may be treated with.!, especially in the hospital, prevention, and enhancing amino acid and protein metabolism cramps subjects. Confirmation by mast cell degranulation test., all rights reserved a muscle group. As the intestines are affected by the deficiency and generally benign, yet often bothersome experience,!

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